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Create a Smart Campaign called something descriptive like Send Email
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In the Smart List tab, drag in the Email Address filter (see image below)
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In the Flow tab, drag in the Send Email flow action.
Once ran, this Smart Campaign would send an email to all leads in your Marketo database minus those with the email addresses in your filter. A good way to exclude domains is to use the
not contains operator coupled with company.com for example:
This should get you on the right track, Stephen. Any more questions, feel free to ask!