You should look at the Field Blocking option in Marketo and decide which fields can never be overwritten by Marketo. Naturally, you'd want to avoid overwriting existing SFDC values like:
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Lead Source
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Addresses
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Phone
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Title
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Name
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Company
Marketo can still add new values to BLANK fields.
Keep in mind that leads will enter in new info that you might want to update, so put that into your deduping plan.