If a lead doesn't accept images - or if for some reason it's not communicated to Marketo that they downloaded the invisible GIF, no Open is associated with the lead.
If they click on a link it's picked up as a click, but now you have more clicks than opens.
If someone clicks on an email link you should assume they opened the email and you should add them in as an Open. This way you always have a 1:1 metric for Clicked to Open.
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