How to unsubscribe emails bulk wise
It would depend on how you have identified all the emails that you want to unsubscribe.
If you have a list of email addresses you want to unsubscribe and they are already in your marketo system, you can identify then in a smart list or import them in a static list and perform a single flow action and set unsubscribe to true.
If you are selecting the emails via some filter criteria, you can do so in a smart list i.e., member of program is tradeshow, or member of static list, or country is not USA, and perform a single flow action and set unsubscribe = true.
Sounds like you want a Batch Campaign » Flow » Change Data Value Unsubscribed = true.
The more detail you provide in your posts, the more we will be able to help (asking complete questions is preferred).