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We have something like this:
1. Leads enter Marketo as L1 - Unqualified Leads
2. At that point in time we check if the meet our L3 - Marketing Qualified Lead criteria (e.g. contact details present)
3. If they are L3, the business unit is determined (e.g. GEO, downloaded files),
and they are pushed to the right business unit queue in Salesforce.
4. If not L3, they are added to nurture programs (tied to the buying journey stage),
and lead status changes to L2 - Marketing Nurture.
5. Inside sales further qualifies the L3 and decides if there is a business potential.
The L3's will be converted to contacts (with or without opportunity) or they are qualified out.
6. Qualified out will be removed from SF and end up in long term programs (e.g. social).
Qualified contacts are now pushed to sales reps and enter Marketo Sales Support programs (tied to opportunity stage).
I have spent a lot of time writing the rules for determining the business unit queue, or determininglead status, but most of all my time was spent on creating the lead life cycle program. Start with your business process first, don't look at the tool (Marketo and Salesforce). E.g. When should your leads be available to sales?