Sure! The details will vary but let's say you know that a certain group of leads came in through a form on a particular page but weren't assigned an aquisition program (maybe you used a global form instead of a local asset etc.)
So you would build a campaign like
SMART LIST (use ALL filters)
Filter: Filled out form = x
Filter: Visited web page = y
FLOW
Change Data Value
Acquisition Program = [your correct program]
etc.
Check the number of leads who qualify in the schedule tab before you run to make sure you are accurately selecting the right people. You may need to get creative and use trial and error with your smart lists so you can accurately target the right groups of people. It all depends what data is available to select them by (form filled out, web page, original referrer, etc.)