When I upload a list like this, it's usually under an email program and I call the list something like "Program Name.List (One Time Use)." Then I send the email with the call to action. Anyone who registers gets pushed to SFDC.
One month later when I close/archive the program, I copy the email stats (Sent, Opened, Clicked) and type those numbers into the SFDC campaign (because they will be altered once you delete the leads). Then I delete anyone on the list who is not a SFDC lead or contact.