Sure.. How many people were unsubscribed, marketing suspended, blacklisted, and email invalid? If you add up those people it could be the missing number of people not sent the email, because they won't qualify to recieve the email. But they will still qualify to be a member of the program.
One way I've seen people deal with this is create a "Global Exclusion" smart list. Smart List | Unsubscribed=True or Mark. Sus. = True or BL = True or E.I. = True. Then when you create your initial smart lists to send out emails, you say Member of Smart List (not in) Global Exclusion list.