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Another pattern I have observed is when sending an email to multiple email addresses at the same domain, the patterns you have noted above regarding timing of the open / click will also happen across every recipient with the same email domain.
I don't believe we can say clicks without opens is 100% a bot pattern though. Here is a screenshot of this pattern on an email I sent myself in Outlook. Outlook clients do not download images by default. I can read the email and click on it, but no open activity will be logged since the pixel tracke...