When both Allow auto-response email rules for Leads and Cases in Marketo and Web-to-Lead in Salesforce are enabled, any record that Marketo inserts into Salesforce will be sent the Default Response Template email selected in the Web-to-Lead Settings in Salesforce, regardless of how that record was initially created in Marketo (form fill, list import, API, etc). This can potentially confuse the end-user, especially if they were inserted into Salesforce because of a list import into Marketo - they are likely not expecting to receive an email from your company. Note that the record will still trigger any appropriate smart campaigns in Marketo, however, the auto-response email will be sent to the record regardless of its marketability or if it has opted-in. If auto-response emails are desired, disable the Allow auto-response email rules for Leads and Cases functionality within Marketo, then set up appropriate smart campaigns to trigger an auto-response email out of Marketo based on specific activities, specifically form fills.
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