So, I just started writing out a long response and realized that it's not that simple. I think the negatives ("not ____") are confusing me.
I think the first step is to add an additional filter for "not clicked link in email" and then select your first email.
The next part is where I get tripped up.... I think using advanced filters, specifying "1 and (2 or 3)," so a member of the smart campaign who didn't open the email -OR- didn't click the email actually only eliminates people who didn't open -AND- didn't click the email.
However, if you use all filters (so, 1 and 2 and 3), that might work. So you're list is looking for someone who is a member of the smart campaign who didn't open the email and didn't click the email. This would mean that opening the email would disqualify you -OR- clicking the email would disqualify you.
Does that make sense? It was confusing to think about!
Depending on your list, you may just want to skip it. It's really only a handful of people in each campaign I send that I see this with...where marketo shows that they clicked a link but doesn't show that they opened the email.