Hi Antonio,
Yes. If Marketo syncs a lead up to SFDC, it will create a new lead even if a similar lead exists in SFDC.
With that said, SFDC automatically syncs all leads/contacts down to Marketo while Marketo only syncs leads up to SFDC when it is told to. So if the lead exists in Salesforce, it will be easy to avoid duplication since you can just make changes to the lead already in Marketo.
Will