Thanks for all your replies! Glad I'm not alone here.
Glen - it would be nice if there was a way to set the guides consistently between editing sessions. I spent a lot of time aligning objects to the guide, closed the window, and when I reopened the guide had reset itself, which made it hard to replace the guide and align another object to the same line.
Either saving the position of the guide, allowing multiple guides, or including some sort of ruler on the x and y axis of the editor would help with consistency.
Thanks again!