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You can also use A/B tests with the email (mailbox) programs, which gives you a wide assortment of testing options. You can test up to 10 different subject lines, different emails and sender details. You can enable Marketo to automatically choose a winner or notify you with the results from a test so you can choose the winner. Depending on how you're using the random sample, these A/B tests features are much more robust and easy to use.
The A/B testing can only test Subject line, Whole email, From address, Date/time. How about I want to test both subject line and email content? I assume that test "whole email" can achieve my goal. But isn't it still hard to fine out which combination test will be better?