Hi Amy,
If you haven't already, I'd create a program for this effort. In the program view, you can create a new SFDC campaign so this will sync over. I
f you do use an email program (depending on all of the efforts you're doing in this campaign) you will see the statuses transfered over to SFDC. But you'll need to make sure and set up smart campaigns for each status. Ex: Campaign "Opens" - the smart list would be TRIGGER Opens email (email name) and then the flow would be status change to Open. Ideally you'll want to set these up before sending the email.
To send the email you'll just need to pull in the smart list - Member of list = (the list that you uploaded) and the flow would be to send the email.
Hope this helps!
Kim