It "should not" impact recipients, but it certainly does regarding landing pages.
Our landing pages render OK in Chrome, Firefox and IE11 but don't display properly in IE8.
Specifically:
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images embedded with the 'image widget' have to be deleted and replaced with an HTML widget containing a simple <img scr="> tag
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Some standalone text boxes don't render at all
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Forms drift around on the page, overwriting text boxes
It's all very well saying "we don't support IE8" but at least 8% of users in Europe (including the multinational corporation that I work for) still use it according to http://theie8countdown.com/