It looks like the difference between "leads affected" and "Sent" is the number of hard/soft bounces and pending, but then the performance report also subtracts those same hard/soft bounces and pending from "Sent" to arrive at "Delivered".
Leads affected prior to the send is the number of leads to whom Marketo will try to send the email. It is the to number of leads that qualify for your smart list criteria less those leads where