Yes, it is possible. Obviously, Marketo has built-in integration with SFDC--but sometimes you need to transfer a lead to an SFDC instance other than your own.
The key is to first enable Web-To-Lead in SFDC in the target system. Salesforce provides some HTML code, and within that is the HTTP POST URL, along with the field names. Skip using the code provided and build a URL for the webhook, which will look something like this--replaicing the X's below with the target SFDC's OID.
https://www.salesforce.com/servlet/servlet.WebToLead?encoding=UTF-8&oid=XXXXXXXXXXXXXXX&email={{lead.Email Address}}&first_name={{lead.First Name}}&last_name={{lead.Last Name}}&phone={{lead.Phone Number}}&company={{company.Company Name}}
You can add additional fields using Marketo tokens--just make sure you have the field name from SFDC properly identified.