You sure can! You need to create a landing page that is the confirmation, so when they click the hyperlink, they go straight to that page. Then, your campaign will have a smart list of "Clicked Link in Email is *whatever the link is*. Then, in your flow steps, you can add them to a list, or a program/campaign, or wherever you are housing these folks.
When someone signs up for anything with us, we always add them to a static "Registration List". Then, we will add an Interesting Moment, update their detailed source if they are new, send a confirmation email to the Lead, as well as send an alert to select members of the Marketing Team. But it just depends on what you are looking to do!