This is a great topic!
Our own testing shows that sending from an actual person lifts the open and click rate. To avoid flooding an person's actual email box with out of office replies and bounces, we set up a general email box then alias the person's first name to that box (john@domain.com, paul@domain.com, etc.). Of course, you have to check that box daily for unsubscribes and replies, but its been worth it.
As for personalization of the recipient's information, we saw an absolute nose-dive in open rates when including a person's name or company name in the subject line. That apparently screams "this is a marketing email", probably because no one actually sends that kind of subject line. Personalizing the message, however, with "Dear Firstname" or "Hello Firstname" did give us a lift in click rates of a few percentage points over messages without the greeting personalization.
Our most effective messages have been those whose appearance mimics that of just a normal email sent from a mail client, complete with greeting and signature. These types of messages are also more likely to elicit a direct reply. There is a time and place for a pretty graphical template, but most of our demand gen and nurture emails are almost entirely text-based in appearance.