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What does "Transaction Failed Spam Message not queued" mean?

Question asked by Kent Brubaker on Mar 12, 2014
When sending our email deployment to a seedlist, all of whom reside at the same company with the same email suffix, out of 144 seeds, 15 get this error and don't receive the email deployment.

554 Transaction Failed Spam message not queued.

So what exactly does this means? And, is this something we can fix in our lead database, or does it have something to do with an outside firewall blocking our emails?

Any help would be appreciated. Thanks.