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I understand the dilemma, but that's reality - some people just aren't interested. The nice thing is you can score those folks and even remove them from the flow eventually.
I wouldn't rely on Opens as the only measure, not all Opens are reported back. So clicks is better. Marketo does a score based on clicks and opens, but you can't really use it for much.
What I have done sometimes (although I don't inherently agree with it) is to have paired streams -
- First Emails
- Non Open/Clicks - these include variations of Email 1 with new subject lines.
Understand the reality. Just wanted to see what options there were.
Thanks Josh this helps!