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Sure you can. The easiest way would be by using 2 lists one for each segment. Then in a smart campaign, the smart list should use Member of List Person in the 2 lists you've created. The Flow should be using Add to Engagement Program, then press on Add Choice, now you should have 2 Choices: Choice 1 - If: Member of List - in - List #1 - Program: Name of the engagement program - Stream: #of the stream you want.
Choice 2 - The same but with the other list and the other stream.
Default Choice should be left untouched.