No it does not.
- You need to combine with the fact that they were sent emails. Without a secondary filter, it will return your whole database.
- Marketo is logging activities and can check that a give activity is missing over a period of time, but missing multiple times does not make sense. as a result, whatever the min number of time, the result will always be the same
In fact I am not sure that you can really achieve what you are looking for. You need to know who was send 2 emails more than the number of email they opened. But in Marketo, if someone opens an email twice, it will record 2 "email opened" events. So if you sent me 10 emails and I opens one of them 10 times, a filter that says "was sent 10 and not opened 10 times" will not select my lead...