Marketo in Higher Ed - using and accessing student data across multiple objects

Hello, I am just wondering if anyone has had any challenges with using marketo within the higher ed space, namely when data is housed in custom objects in Salesforce.  Does Marketo need to be heavily customized to be able to run smart campaigns and send emails based on student enrollment and engagement  (grades/attendance/application status by program, etc)

Is there any documentation around these use cases? Thanks!