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There should not be any automatic removal or deletion of your records in Marketo based on the status changing (unless you build a rule to delete them). What I interpret this to mean is that a record created in SFDC with a status = Disqualified will not be synced to Marketo (created or updates passed). So again, my understanding of this is that this restriction keeps records with that status from being created in Marketo (if they don't exist) or from syncing data from SFDC to Marketo (with that status).
If you're really concerned, it never hurts to test a record and monitor the behavior between they systems.