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without seeing the code or how you built the link, this is hard to say. Yes, it is possible a particular spam filter stripped the link somehow. I've also had weird moments where the links in an email just don't work in a particular client.
There is also a known issue where you could place the image or a container over the link/image in such a way as to make it not possible to click. Haven't seen that too often.
What I'd like to see is the full HTML body of the received email for one of these exceptional leads.
Then (if you can) retest with one of these leads and a generic URL like www.example.com to see if that, too, is stripped.
Do you use conditional code for Outlook clients by chance? Sometimes people forget to update both the Outlook and non-Outlook versions of content to have the same links. Like Josh said, that could result in an email not working the same across all email clients.