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Welcome to Marketo.
Renaming assets in general does not break anything because when those assets are referenced, their new names will be referenced. For example let's say in a smart campaign you are referencing "Member of Smart List: Created 8/3/17". If you were to rename that smart list to "Created 8/4/17" and check back to that smart campaign, it will now show "Member of Smart List: Created 8/4/17". To be safe, before you rename, you can reference the "Used By" tab of any asset to see what other assets are referencing it.
Also check out this resource: Help! I've Inherited an Existing Marketo Instance - Marketo Docs - Product Docs