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Firstly, please move this discussion to Products to receive a more prompt response.
As for your question, yes what you can do is in the smart list for the reminder send, bring in the filter:
filter: Not Clicked Link in Email
constraint: Email is: (select first email)
constraint: Link is: (select link in first email)
delete the default Date of Activity constraint
The resulting list will exclude any people who have clicked the defined link in the first email. Make a note however, that not all clicks in that email will have been from the actual person themselves. See: Email was clicked before it was delivered? It's a link scanner