There are several threads on this.
How are you defining "invalid". Would highly recommend NOT emailing those people as it will hurt your reputation.
Hi Tara, if you already have something in place for hard bounces you should be marking those as either invalid or suspended. If you've put a reason for it, that's also helpful because you can review later on why they were invalid or suspended.
I agree with Josh, if you've already decided that email addresses are invalid, I would highly recommend not emailing them again.
I'd also suggest reviewing soft bounces because those can also be an indicator of invalid email addresses even if there isn't a hard bounce. Most of what you want to accomplish should be done looking anecdotally at previous sends rather than a new send, because you're just going to harm your reputation further by continuing to email names that should be removed.