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If it's not sent from Marketo or Sales Insight, you can't track it.
It may be possible to setup some sort of third party wrapper, but I doubt that's worth the effort.
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You could try using Google Analytics. See details here: Email Tracking - Measurement Protocol | Analytics Measurement Protocol | Google Developers
It won't give you opens at an individual lead level, but at least you could have an aggregated number of opens.
Actually, if all you want is the aggregate number of image-enabled opens of an email sent outside of Marketo, you can track that quite easily using Marketo alone.
Tracking 3rd-party clicks (via their resulting Visits Web Page events, not as literal Clicks Email events) requires more preparation but is also possible.
'bout the only thing that's really out of reach to most people is tracking 3rd-party opens down to the lead level. Of course opens don't really represent the number of people who looked at the non-image-enabled or text-only versions of your emails (I know you know that, Jose, but not everyone gets that yet).