Opened email / Not opened email is very unreliable as it is based only on picture download. You will remove people who are engaged with your content and consider as engaged people who has just browsed through their emails...
I would strongly recommend NOT to remove people from streams based on this signal only.
Now, if you really want to do it, if you add all the 17 emails to the filter, it will take anyone who has not opened at least 1 of the emails, even if they have opened the 16 others.
If you want to remove any one who has not opened any of the 17 emails, create a smart list "opened email", with the 17 emails in the filter, then take any one who is not a member of this smart list.
Great point! I will add all activity filters to this. (Opens, clicks, form fills).