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Well, that depends I guess. With Marketo there are a couple options to accomplish this.
1) In Marketo you can call web services directly from any workflow. So if this 3rd party data source has web services enabled then it is entirely possible to leverage those directly from marketo.
2) If not then you can use Marketo APIs to take data from the 3rd party data source and push that into Marketo.
Either way, these techniques are described in full right here: developers.marketo.com