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This depends on the load on your system and the complexity of the list. Usually if a list is over 10 minutes, I try again.
When you say you have 4 lists, do you mean 4 smart lists, or 4 static lists? Smart lists will take longer.
If your Exclusion list is just Unsubscribe=T, this is unnecessary because Marketo blocks them anyway. Try removing that list to help.
If you are getting 0, are you sure your Suppression is Member NOT IN Suppression?