No, this is not possible. If you look at the docs.marketo.com it only permits 3 or 4 options, fewer than Email Send.
I do not recommend creating this matrix because it will be very hard to track without the proper tools.
Instead, create separate streams or nurtures for the personas you intend to target and then use Champ/Challenger so you can compare 1-1 more easily.
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I agree with Josh, this is better done with three campaigns and then manage when a user goes into the campaign
Thank you Josh. I thought creating separate streams might be the best approach.