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It is best practice to include all of your North America time zones on both the Landing Page, Email Invites and WebEx, we write all the main time zones like this:
In WebEx we also select multiple time zone on the Time zone section when creating or updating a Webinar:
As for the Calendar reminder file in Marketo, it's actually specific to the persons computer Time Zone and not what you have in the ics file, we set it in whatever time zone Marketo is set in, but that doesn't mean it's fixed, i.e. if the Calendar reminder is set for 11am CT but a person in New York downloads it, then it will show up at 12pm on there calendar.
Also, in terms of choosing a base time, it is up to you. If you only work in NA, then choose a time that covers East to West coast reasonably. An internet search will find some baseline data on the "best' time for webinars. Most firms do 10-12 ET or 1p ET.
If you want to hit Europe and NA at the same moment, 11a ET usually works. Sometimes I used to do two live sessions - 1 UK time and 1 EST.
But with video recording, it really doesn't matter anymore.