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Amongst other things :
- You now benefit from a more sophisticated field right management in SFDC. This means that you can remove some fields from pages layouts in SFDC without damage (provided that the Marketo user can still access them). You will therefore be able to streamline the information made available to sales in SFDC to what's really essential to them
- You also benefit from SFDC triggers, flows, business processes and APEX developments that would enable you to do some much more sophisticated things in SFDC, such as creating some assistants for lead acceptance, conversion or dismissal
In addition, the process is well documented, so take a look at
for a deeper understanding. What Greg said is the key difference and probably only big change you would even need to make.