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you can segment them using a list but you could also segment them by updating a "subscription type" or whatever field. It really depends on your requirements in my opinion.
If you use a list it doesn't matter if they already exist or not. If they don't exist they will be created, if they exist they will be matched.
A static list would work, or you could create a custom field for each type of group and then when you send communications, just filter based on that.