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David, generally clicks (a real action taken) are considered a higher level of engagement than Opens. Opens are unreliable because they depend on the user downloading an image in their email viewer. Some viewers block automatically, so Opens can be directional overall. Now, if they did get marked as Open, they may (or may not) have read your email. In a preview pane, I'll glance and then delete.
So you can totally do what you suggest because at least the Opens have a higher likelihood of clicking on a second email. In terms of point values and other value, clickers are what you want.