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Is any email flagged by spam filters marked as invalid? It is likely.
The article "Soft and hard Bounces in Email" clarifies the nature and impact of each type
Bgomes is probably right on this one. I'd just like to add though that I've found a helpful way to avoid seeing a high "blocked from mailings" number is creating a global smart list that factors out any addresses that would be ineligible for mailings in the first place. These filters include:
Opt Out: False
Email address is not blank
Black list: False
Email Invalid: False
Marketing Suspended: False
I then reference this smart list (I call it "Eligible for mailings") in every outbound email campaign i send. It helps me get a much more accurate prediction of send size, and it reduces the head scratching.
Thanks for both of your suggestions and information!