It might be worth putting together some dashboards and utilizing Prompts so that you can simply select the lists you want. You can set the default selections in the dashboard, so you only have to change your include/exclude logic right in the dash, and it will let you change up to 9 at a time. For channels you want to remove, you can go into the Admin>Channels>Tags section and make those channels invisible to RE. If you get into the habit of only including the channels you need in RE in the Admin section it might make it a cleaner update.
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