I have sent one email send and will be sending a reminder email, but would like to exclude those who have clicked in the first email. Is that possible and if so how?
Firstly, please move this discussion to Products to receive a more prompt response.
As for your question, yes what you can do is in the smart list for the reminder send, bring in the filter:
filter: Not Clicked Link in Email
constraint: Email is: (select first email)
constraint: Link is: (select link in first email)
delete the default Date of Activity constraint
The resulting list will exclude any people who have clicked the defined link in the first email. Make a note however, that not all clicks in that email will have been from the actual person themselves. See: Email was clicked before it was delivered? It's a link scanner